Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ventilator-induced lung injury.

Jean-Damien Ricard1, Didier Dreyfuss, Georges Saumon

  • 1Service de Réanimation Médicale, Hôpital Louis Mourier, Colombes, France. jean-damien.ricard@imr.ap-hop-paris.fr

Current Opinion in Critical Care
|September 3, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The UNDERSCORE for RRT weaning prediction: promising but not yet ready to unplug. Author's reply.

Intensive care medicine·2026
Same author

Management of hypercapnic acute respiratory failure with high-flow nasal cannula therapy: A narrative review.

Annals of intensive care·2026
Same author

Relation between initial hypothermia, course of the hypothermia and mortality in patients with septic shock: a post-hoc analysis of the SEPSISPAM randomized trial.

Annals of intensive care·2026
Same author

Predictive factors of successful renal replacement therapy weaning : Deciding On patients Orientations after Renal replacement therapy Stopping (The DOORS study).

Intensive care medicine·2026
Same author

Prognosis of critically ill patients with severe acute kidney injury and high circulating dipeptidyl peptidase 3: a post hoc analysis of the AKIKI 2 trial.

Critical care (London, England)·2026
Same author

Early biomarker detection: fundamentally disputable? Authors' Reply.

Intensive care medicine·2026

Reducing tidal volume during mechanical ventilation significantly lowers mortality in patients with acute respiratory distress syndrome. This confirms that excessive lung volumes cause ventilator-induced lung injury.

Area of Science:

  • Pulmonary Medicine
  • Critical Care Medicine
  • Mechanical Ventilation

Background:

  • The clinical significance of ventilator-induced lung injury (VILI) is underscored by recent trials.
  • Excessive tidal volume and end-inspiratory lung volume are primary drivers of VILI.
  • The Acute Respiratory Distress Syndrome Network trial demonstrated a 22% mortality reduction by lowering tidal volume.

Purpose of the Study:

  • To confirm the clinical relevance of VILI and its primary determinants.
  • To highlight the role of inflammatory cells and mediators in VILI pathogenesis.
  • To investigate cellular responses to mechanical stress in the context of VILI.

Main Methods:

  • Analysis of data from the Acute Respiratory Distress Syndrome Network trial.

Related Experiment Videos

  • Review of experimental observations on VILI.
  • Focus on inflammatory pathways and cellular responses to mechanical stress.

    • Main Results:

    • Mechanical ventilation with reduced tidal volume led to a 22% decrease in mortality for acute respiratory distress syndrome patients.
    • Experimental evidence confirms excessive tidal volume as the key determinant of VILI.
    • Inflammatory cell and mediator involvement in VILI pathogenesis is increasingly recognized.

    Conclusions:

    • Lung-protective ventilation strategies, specifically tidal volume reduction, are clinically validated for reducing mortality in acute respiratory distress syndrome.
    • Understanding the mechanisms of VILI, including inflammatory responses, is crucial for improving patient outcomes.
    • Further research into cellular responses to mechanical stress is warranted to refine VILI prevention and treatment.