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Double arterial phase dynamic MRI with sensitivity encoding (SENSE) for hypervascular hepatocellular carcinomas
Hiroshi Yoshioka1, Nobuyuki Takahashi, Masayuki Yamaguchi
1Department of Radiology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan. hir-yosh@md.tsukuba.ac.jp
Journal of Magnetic Resonance Imaging : JMRI
|September 3, 2002
Summary
SENSE MRI with a double arterial phase dynamic study significantly improves the detection of hypervascular hepatocellular carcinomas (HCCs) compared to conventional MRI. This advanced technique offers higher sensitivity, especially for smaller HCCs, making it a promising tool for early diagnosis.
Area of Science:
- Radiology
- Medical Imaging
- Oncology
Background:
- Hepatocellular carcinoma (HCC) is a primary liver malignancy.
- Early and accurate detection of HCC is crucial for effective treatment.
- Hypervascular HCCs present a diagnostic challenge in medical imaging.
Purpose of the Study:
- To evaluate the efficacy of SENSE MRI, incorporating a double arterial phase dynamic study.
- To compare the diagnostic performance of SENSE MRI against conventional MRI for detecting hypervascular HCCs.
Main Methods:
- Liver MRI was performed on 40 patients, with 20 undergoing conventional MRI and 20 using SENSE MRI.
- SENSE MRI utilized breath-hold T1-weighted FSE and dynamic imaging sequences.
- A double arterial phase and double portal phase dynamic study was implemented with SENSE MRI.
Main Results:
- SENSE MRI demonstrated a higher sensitivity (91.7%) for HCC detection compared to conventional MRI (76.3%).
- The positive predictive value for SENSE MRI was 91.7%, versus 87.9% for conventional MRI.
- SENSE MRI significantly improved the detection of small HCCs (≤10 mm) with higher sensitivity and positive predictive values.
Conclusions:
- SENSE MRI with a double arterial phase dynamic study is more sensitive for detecting hypervascular HCCs than conventional MRI.
- SENSE MRI shows significant promise as an advanced imaging method for HCC diagnosis.
- The technique offers improved detection rates, particularly for small and potentially early-stage HCC lesions.