Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Midodrine in neurally mediated syncope: a double-blind, randomized, crossover study.

Horacio Kaufmann1, Daniela Saadia, Andrei Voustianiouk

  • 1Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA. horacio.kaufmann@mssm.edu

Annals of Neurology
|September 3, 2002
PubMed
Summary

Midodrine effectively prevents neurally mediated syncope, a common cause of fainting. This study showed midodrine significantly reduced syncope episodes during head-up tilt tests in affected patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autonomic Dysfunction in Long COVID Is Distinct From Pure Autonomic Failure.

Journal of the American College of Cardiology·2026
Same author

Prospective Validation of the Movement Disorder Society Prodromal Multiple System Atrophy Criteria in Pure Autonomic Failure.

Movement disorders : official journal of the Movement Disorder Society·2026
Same author

Addressing the needs of nano-rare patients: the n-Lorem experience.

Nucleic acids research·2026
Same author

Long-term outcomes of hyperadrenergic orthostatic hypotension.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2026
Same author

Multiple System Atrophy Combined Outcome Assessment (MuSyCA): process, format, and validation plan.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2026
Same author

Clinical autonomic research: welcome to 2026.

Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2026

Area of Science:

  • Cardiology
  • Neurology
  • Pharmacology

Background:

  • Neurally mediated syncope is the most common cause of fainting in individuals without heart disease.
  • A frequent trigger for this condition is reduced venous return to the heart due to blood pooling in the legs.

Purpose of the Study:

  • To assess the effectiveness of midodrine, an alpha-1 adrenergic agonist, in preventing neurally mediated syncope.
  • Investigate midodrine's role in improving orthostatic tolerance during passive head-up tilt tests.

Main Methods:

  • A double-blind, randomized, crossover trial involving 12 patients with recurrent neurally mediated syncope.
  • Patients received either a 5mg dose of midodrine or a placebo, followed by a 60-degree head-up tilt test.

Main Results:

Related Experiment Videos

  • Midodrine administration did not significantly alter blood pressure or heart rate in the supine position.
  • During head-up tilt, syncope occurred in 67% of patients on placebo versus 17% on midodrine (p < 0.02).

Conclusions:

  • Midodrine significantly enhances orthostatic tolerance in patients experiencing recurrent neurally mediated syncope.
  • This medication demonstrates efficacy in preventing syncope triggered by passive head-up tilt.