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[Antihypertensive study of xingnao qingxuan recipe]
1National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050.
Objective:
To observe the effect of decreasing blood pressure of Xingnao Qingxuan Casuples.
Method:
The blood pressure in normal and anesthetised cats was examined with direct method, the blood pressure in the conscious SHR was obtained by indirect method.
Results:
Duodenuos administration(id) of XQC of 2.8 g/kg produced a decrease of blood pressure in normal cats; XQC of 1.4, 2.8 and 5.6 g/kg once a day for 14 days produced a dose-dependent reduction of blood pressure in SHR, 3-4 days after administration the blood pressure returned to the level before but the change was not significant. With gastric administration of XQC of 2.8 and 5.6 g/kg for 3 times, the incubation period of eyeball tremor induced by chloroform by dropping into the ear was prolonged by 14.4% and 13.0%, and the keeping time shortened by about 33.3% and 23.3% respectively. Brain basic arterial spasm induced by KCl or 5-HT in dog was relaxed obviously by XQC in vitro experiment.
Conclusion:
XQC has the effect of reducing blood pressure resisting dizziness, which is related to the diastole of brain blood vessel.