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[A study on characteristics of transdermal absorption of Radix Angelieae Sinensis and its compound formula]
1Shanghai University of Traditional Chinese Medicine and Pharmacy, Shanghai 200032, China.
Objective:
To investigate the characteristics of transdermal absorption of Radix Angelieae Sinensis and its compound formula.
Method:
Using Valia-Chien diffusion cell in vitro, and HPLC to determine the content of ferulic acid(FA).
Result:
The transdermal permeability coefficient (PC)pf FA, which is the main ingredient of Radix Angelieae Sinensis, is greater than that of the monomer (P < 0.01): the PC of FA is decreased when Radix Angelieae Sinensis and Salviae Miltiorrhizae are used together (P < 0.01): borneol helps enhance the permeation of Radix Angelisas Sinensis (P < 0.01); the PC of the compound formula is greater than that of the compatibility (P < 0.01).
Conclusion:
The transdermal absorption of an ingredient of a traditional Chinese drug is affected not by compatibility, but also by other ingredients of the drug. The transdermal absorption of a monomer or a single drug could not fully mirror the absorption of a compound formula.