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[Heat shock protein 70 expression following transient ischemia in the gerbil]
1Institute of Neurology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Objective:
To study the expression of heat shock protein 70(HSP70) following transient ischemia in the gerbil.
Methods:
Immunohistochemistry(IHC) was used to determine the expression of the HSP70 protein in the forebrain during different periods after post-ischemic reperfusion in the gerbil, and the neuronal damage was examined with microscope.
Results:
The HSP70 protein was only expressed at the 1st day of reperfusion(P < 0.01); and most of the neurons showed damage on the 7th day of reperfusion; heat-preconditioning could increase the expression of HSP70 protein(P < 0.01) and decrease the neuronal damage(P < 0.001) after 6 min of ischemia.
Conclusion:
Heat-preconditioning could protect neural cells from damage by increasing the expression of the HSP70 protein.
