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Updated: Sep 29, 2026

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
Published on: May 24, 2017
A comparison of sustained-release bupropion and placebo for smokeless tobacco cessation
Elbert D Glover1, Penny N Glover, C Rollynn Sullivan
1Addiction and Psychiatric Medicine Research, West Virginia University School of Medicine, Morgantown 26506-9135, USA. eglover@hsc.wvu.edu
Objective:
To evaluate the potential efficacy of bupropion sustained release when used in combination with minimal counseling for moist snuff cessation in males.
Methods:
A double-blind, placebo-controlled 3-month trial. The active treatment group (n = 35) received bupropion SR at 150 mg/qd day for the first 3 days, then beginning day 4 through day 49 (7 weeks) 150 mg/ b.i.d. The placebo group (n= 35) received 1 tablet qd for 3 days and beginning day 4 through day 49, 1 tablet/b.i.d.
Results:
Bupropion 300 mg/day (150 b.i.d.) produced significantly higher quit rates for smokeless tobacco cessation at the end of treatment (7 weeks) than placebo (p = 0.04) with an OR of 2.73.
Conclusion:
Bupropion SR appears to be effective for smokeless tobacco cessation.
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