Search research articles

Search research articles

Related Experiment Videos

Rasmussen's encephalitis followed by lupus erythematosus.

K Lascelles¹, A F Dean, Richard O Robinson

¹Newcomen Centre, Guy's Hospital, London, UK. karine.lascelles@kcl.ac.uk

Developmental Medicine and Child Neurology

|September 11, 2002

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Real-Time Suicide Surveillance: Comparison of International Surveillance Systems and Recommended Best Practice.

Archives of suicide research : official journal of the International Academy for Suicide Research·2022

Same author

Post-mortem confirmation of fetal brain abnormalities: challenges highlighted by the MERIDIAN cohort study.

BJOG : an international journal of obstetrics and gynaecology·2020

Same author

New SMARCA2 mutation in a patient with Nicolaides-Baraitser syndrome and myoclonic astatic epilepsy.

American journal of medical genetics. Part A·2016

Same author

Early-onset movement disorder and epileptic encephalopathy due to de novo dominant SCN8A mutation.

Seizure·2015

Same author

Temozolomide responsiveness in aggressive corticotroph tumours: a case report and review of the literature.

Pituitary·2011

Same author

Correlation of MR relative cerebral blood volume measurements with cellular density and proliferation in high-grade gliomas: an image-guided biopsy study.

AJNR. American journal of neuroradiology·2010

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Rasmussen's encephalitis (RE) in a child led to intractable seizures and hemiplegia, successfully treated with hemispherectomy. Later, the patient developed systemic lupus erythematosus (SLE), suggesting a potential link between these conditions.

Area of Science:

Neurology
Pediatric Neurology
Autoimmune Diseases

Background:

Rasmussen's encephalitis (RE) is a rare, chronic inflammatory neurological disease affecting one cerebral hemisphere, typically in children.
It often presents with progressive neurological deficits, including motor impairments and intractable epilepsy.
The etiology of RE remains unclear, though autoimmune mechanisms are suspected.

Observation:

A 6-year-old female initially presented with hemichorea, progressing to hemiplegia and intractable focal to generalized tonic-clonic seizures.
Brain biopsy confirmed Rasmussen's encephalitis (RE).
A left hemispherectomy at 9.5 years resulted in seizure resolution and good recovery.

Findings:

At age 12, the patient developed recurrent abdominal pain, fever, and malar rash, consistent with systemic lupus erythematosus (SLE).

Related Experiment Videos

Serological tests confirmed SLE.

This case presents a potential association between RE and SLE.

Implications:

The co-occurrence of RE and SLE in this patient suggests a possible shared autoimmune pathogenesis or a link between these distinct conditions.
Further research is warranted to explore potential connections between neuroinflammatory and systemic autoimmune diseases.
This case highlights the complex and varied clinical manifestations of autoimmune disorders in children.