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Published on: April 17, 2012
Radiotherapy for perianal Paget's disease
R S D Brown1, K J Lankester, M McCormack
1Meyerstein Institute of Oncology, Middlesex Hospital, London, UK. richard.brown@bartsandthelondon.nhs.uk
Clinical Oncology (Royal College of Radiologists (Great Britain))
|September 11, 2002
Summary
Radiotherapy can be a primary treatment or used after surgery for perianal Paget's disease (PPD). Further research and publication of radiotherapy cases are needed to define optimal treatment protocols for PPD management.
Area of Science:
- Oncology
- Radiation Oncology
- Dermatology
Background:
- The role of radiotherapy in managing perianal Paget's disease (PPD) lacks clear definition in clinical practice and literature.
- Existing published data on PPD radiotherapy is often sporadic and lacks technical detail.
Purpose of the Study:
- To present 6 cases of PPD treated with radiotherapy, detailing treatment specifics and outcomes.
- To conduct a comprehensive literature review to identify published PPD cases and radiotherapy utilization.
- To further delineate the potential roles of radiotherapy in PPD management.
Main Methods:
- Case series presentation of 6 PPD patients receiving radiotherapy.
- Systematic literature search for published PPD cases and radiotherapy use.
- Review of documented radiotherapy techniques, doses, and patient outcomes.
Main Results:
- Radiotherapy demonstrated utility as both primary treatment for in situ/invasive PPD and post-surgical relapse management.
- Identified potential roles in neoadjuvant, adjuvant, and chemoradiotherapy settings.
- Presented treatment outcomes for both in situ and invasive PPD cases.
Conclusions:
- Radiotherapy has a defined role in perianal Paget's disease management, contrary to some surgical literature views.
- Precise technical recommendations (dose, fractionation, margins) are challenging due to limited data.
- Encouraging publication of radiotherapy experiences is crucial for establishing evidence-based guidelines.
