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Peritoneal membrane failure in peritoneal dialysis patients
Raymond T Krediet1, Ssadie Van Esch, Watske Smit
1Division of Nephrology, Department of Medicine, Academic Medical Center University of Amsterdam, and Dianet Foundation, Utrecht, The Netherlands. m.a.zeeman@amc.uva.nl
Blood Purification
|September 11, 2002
Summary
Peritoneal membrane failure, often seen as ultrafiltration failure, is linked to high solute transport rates. This suggests an enlarged peritoneal surface area, either functional or anatomical, contributes to the condition.
Area of Science:
- Nephrology
- Renal Medicine
- Peritoneal Dialysis
Background:
- Peritoneal membrane failure is a critical complication in peritoneal dialysis.
- Ultrafiltration failure is the primary clinical manifestation of peritoneal membrane failure.
Purpose of the Study:
- To review conditions and causes of peritoneal membrane failure.
- To elucidate the relationship between solute transport and peritoneal surface area.
Main Methods:
- Literature review of studies on peritoneal dialysis complications.
- Analysis of factors contributing to peritoneal membrane dysfunction.
Main Results:
- Ultrafiltration failure is associated with high transport rates of low molecular weight solutes.
- A large vascular surface area is suggested by high solute transport.
- Peritoneal surface area enlargement can be functional (increased perfusion) or anatomical (increased microvessels).
Conclusions:
- Functional enlargement may occur early in peritoneal dialysis or during peritonitis.
- Anatomical enlargement can develop with long-term peritoneal dialysis.
- Understanding these mechanisms is key to managing peritoneal membrane failure.