New insights in the role of Bcl-2 Bcl-2 and the endoplasmic reticulum

J Rudner1, V Jendrossek, C Belka

  • 1Department of Radiation Oncology, University of Tuebingen, Hoppe-Seyler Str. 3, D-72076 Tuebingen, Germany.

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ER Retrieval Pathway

In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
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The Endoplasmic Reticulum

The endoplasmic reticulum or ER makes up for more than half of the membranes in a cell and accounts for 10% of total cell volume. It is also the primary protein and lipid synthesis factory for most cell organelles, such as the Golgi apparatus, lysosomes, secretory vesicles, and the plasma membrane. Despite being the most extensive and functionally complex subcellular organelle, ER was the last to be discovered. After years of deliberation, Keith Porter and George Palade in the year 1954,...
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Targeting proteins to the ER
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Export of Misfolded Proteins out of the ER

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