Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Vomiting].

M Camici1

  • 1Dipartimento di Medicina Interna, Università degli Studi di Pisa, Pisa, Italy.

Minerva Medica
|September 11, 2002
PubMed
Summary
This summary is machine-generated.

Nausea and vomiting are basic neural reflexes that remain poorly understood, hindering effective drug development. This review summarizes current knowledge on the anatomy and neurochemistry of vomiting, focusing on serotonin and substance P, to improve treatments for chemotherapy-induced and postoperative nausea and vomiting.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ocular involvement in monkeypox: Description of an unusual presentation during the current outbreak.

The Journal of infection·2022
Same author

A 72-h intervention for improvement of the rate of optimal antibiotic therapy in patients with bloodstream infections.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2017
Same author

Cell proliferation and drug sensitivity of human glioblastoma cells are altered by the stable modulation of cytosolic 5'-nucleotidase II.

The international journal of biochemistry & cell biology·2015
Same author

The purine analog fludarabine acts as a cytosolic 5'-nucleotidase II inhibitor.

Biochemical pharmacology·2015
Same author

Partial purification and characterization of a proteolytic activity of alfalfa juice.

Journal of agricultural and food chemistry·2009
Same author

The phosphotransferase activity of cytosolic 5'-nucleotidase; a purine analog phosphorylating enzyme.

The international journal of biochemistry & cell biology·2009
Same journal

How to become a centenarian in four weeks?. Myths and limits of longevity recipes: a critical review.

Minerva medica·2026
Same journal

Comparative efficacy and safety between intravenous recombinant human prourokinase and alteplase in acute ischemic stroke treatment: a meta-analysis of randomized controlled trials.

Minerva medica·2026
Same journal

Efficacy and safety of oral tapentadol for cancer-related pain: an updated systematic review and meta-analysis.

Minerva medica·2026
Same journal

Use of the neurostimulator in thyroidectomy procedures: comparison between vagal and recurrent laryngeal nerve stimulation.

Minerva medica·2026
Same journal

Iron deficiency and risk of acute kidney injury after TAVI: a machine learning analysis.

Minerva medica·2026
Same journal

Therapeutic adherence and health literacy: a perfect match in dyslipidemic patients.

Minerva medica·2026
See all related articles

Area of Science:

  • Neuroscience
  • Pharmacology
  • Gastroenterology

Context:

  • Nausea and vomiting are fundamental protective reflexes across vertebrates, yet their underlying pathogenetic mechanisms, particularly from neuroendocrine and receptor perspectives, are not fully elucidated.
  • This lack of understanding contributes to the variable efficacy of antiemetic drugs across different types of vomiting.
  • The neurochemical and neuropharmacological underpinnings of the vomiting reflex present a significant area for continued research.

Purpose:

  • To synthesize current scientific understanding of the anatomy of the vomiting reflex.
  • To review neurotransmitter receptor subtypes, and the roles of serotonin and substance P agonists and antagonists.
  • To specifically address the application of this knowledge in managing post-chemotherapy and postoperative nausea and vomiting.

Related Experiment Videos

Summary:

  • The paper provides a comprehensive overview of the neuroanatomy and neuropharmacology of the vomiting reflex.
  • It details the involvement of specific neurotransmitters, focusing on serotonin and substance P pathways, and their receptor interactions.
  • Current therapeutic strategies for chemotherapy-induced and postoperative nausea and vomiting are discussed in light of this neurochemical understanding.

Impact:

  • Improved understanding of vomiting mechanisms can lead to more targeted and effective antiemetic drug therapies.
  • Identifying key neurochemical pathways may reveal novel therapeutic targets for managing nausea and vomiting.
  • Research into vomiting mechanisms and treatments could yield insights applicable to other conditions, such as migraine, rheumatoid arthritis, and bronchial asthma.