Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Statistical analysis of tablet breakability methods.

Lieven Van Vooren1, Bart De Spiegeleer, Thomas Thonissen

  • 1Health Engineering and Assurance (HEA), Gent, Belgium.

Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Societe Canadienne Des Sciences Pharmaceutiques
|September 5, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world evidence on In-hospital statin use and mortality in geriatric patients.

Acta clinica Belgica·2026
Same author

Navigating in the chemical space of peptides: computational strategies and molecular features to unveil their functional and drug-like properties.

Physical chemistry chemical physics : PCCP·2026
Same author

Imaging brain development in a KCNQ2-developmental and epileptic encephalopathy mouse model: identifying early biomarkers for functional and structural brain changes.

EBioMedicine·2026
Same author

Role of Peptides in Skeletal Muscle Wasting: A Scoping Review.

Journal of cachexia, sarcopenia and muscle·2025
Same author

Beyond Molecular Weight: Peptide Characteristics Influencing the Sensitivity of Retention to Changes in Organic Solvent in Reversed-Phase Chromatography.

ACS omega·2025
Same author

The association between statins and gait speed reserve in older adults: effects of concomitant medication.

GeroScience·2025
Same journal

Old drugs, new weapons: current trends in repurposing therapies against antimicrobial resistance.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques·2026
Same journal

Dissolution-permeation approach for biopharmaceutical evaluation: a feasibility study using naproxen.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques·2026
Same journal

Practical considerations for managing patients being treated with topical roflumilast.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques·2026
Same journal

Artificial intelligence directed computational protein design: lessons from COVID-19 for pandemic-ready vaccines and antibody therapeutics.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques·2026
Same journal

Qualitative phytochemical profiling, antioxidant activity, and development of a water-in-oil cream containing combined oil and water infusions of frankincense resin (<i>Boswellia spp.</i>): a preliminary <i>in vitro</i> study.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques·2026
Same journal

Ketamine enhancement of dexmedetomidine attenuation of methamphetamine-induced agitation in rats.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques·2026
See all related articles

Tablet breakability methodology significantly impacts mass uniformity of broken halves and quarters. Applying force towards the score ("opening" the score) yields the best results for mass consistency.

Area of Science:

  • Pharmaceutical technology
  • Drug delivery systems
  • Solid dosage form manufacturing

Background:

  • Tablet fragmentation is crucial for dose adjustment.
  • Ensuring mass uniformity of broken tablets is essential for accurate dosing.
  • Breakability methodology can influence the uniformity of fragmented tablets.

Purpose of the Study:

  • To investigate the impact of breakability methodology on the mass uniformity of half- and quarter-tablets.
  • To compare different data acquisition and evaluation approaches for tablet breakability.
  • To compare various breakability evaluation criteria using distribution- and distribution-free models.

Main Methods:

  • Utilized a model tablet with two score lines for breakage studies.
  • Employed different breaking methodologies and involved multiple individuals.

Related Experiment Videos

  • Determined the masses of whole, half, and quarter tablets post-fracture.

    • Main Results:

    • Breakability methodology was the primary factor influencing mass uniformity, more so than the individual breaking the tablet.
    • Optimal mass uniformity (minimal loss and variability) was achieved when force was applied towards the score line, facilitating an "opening" motion.
    • The USP/NF evaluation criterion aligned best with detailed analysis of all broken tablets.

    Conclusions:

    • The standard deviation of quarter-tablets was theoretically calculated to be 0.87 times that of half-tablets, assuming linear variance with break-line length.
    • While absolute standard deviation remained similar, relative standard deviation nearly doubled for quarter-tablets due to halved mean mass.
    • Experimental results confirmed the theoretical predictions regarding mass uniformity and relative standard deviation.