Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Numerical modelling of the accommodating lens.

H J Burd1, S J Judge, J A Cross

  • 1Department of Engineering Science, University of Oxford, Parks Road, OX1 3PJ, Oxford, UK. harvey.burd@eng.ox.uk

Vision Research
|September 5, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigation of The Effects of Prosthetic Knee Condition for Individuals with Transfemoral Amputation During Attempted Running.

Canadian prosthetics & orthotics journal·2023
Same author

Trichloroethylene and its metabolite TaClo lead to degeneration of substantia nigra dopaminergic neurones: Effects in wild type and human A30P mutant α-synuclein mice.

Neuroscience letters·2019
Same author

Equatorial wrinkles in the human lens capsule.

Experimental eye research·2017
Same author

Finite element modelling of radial lentotomy cuts to improve the accommodation performance of the human lens.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2016
Same author

Finite element implementation of a multiscale model of the human lens capsule.

Biomechanics and modeling in mechanobiology·2015
Same author

Plasma and synovial fluid concentration of doxycycline following low-dose, low-frequency administration, and resultant inhibition of matrix metalloproteinase-13 from interleukin-stimulated equine synoviocytes.

Equine veterinary journal·2013
Same journal

Impact of crowding on visual appearance and performance in amblyopia.

Vision research·2026
Same journal

Editorial for VSI Amblyopia: Advances in Amblyopia Research.

Vision research·2026
Same journal

Computational and mathematical models in vision: Quantitative approaches to understanding visual perception.

Vision research·2026
Same journal

Complex interactions between lightness, chroma, and hue in color ensemble perception.

Vision research·2026
Same journal

Driving with autism spectrum disorder: Exploring the impact of tactile hazard warnings on gaze behavior and hazard responses.

Vision research·2026
Same journal

Early visual processing in adults with ADHD: evidence from contrast sensitivity, spatial integration, and external noise.

Vision research·2026
See all related articles

Finite element models of the human eye lens show reduced accommodation with age. This computational approach captures key features of presbyopia, offering insights into age-related vision changes.

Area of Science:

  • Ophthalmology
  • Biomechanical Engineering
  • Computational Biology

Background:

  • Age-related changes in the human lens affect its accommodative ability.
  • Presbyopia, the loss of near-focusing ability, is a common age-related condition.
  • Understanding the biomechanics of the aging lens is crucial for developing interventions.

Purpose of the Study:

  • To develop and validate finite element models of the human eye lens across different age groups.
  • To investigate the age-related decline in lens accommodation using computational modeling.
  • To explore the biomechanical factors contributing to presbyopia.

Main Methods:

  • Construction of axisymmetric, large displacement, finite element models of the human lens.
  • Incorporation of geometric and material properties from published data for nucleus, cortex, capsule, and zonule.

Related Experiment Videos

  • Modeling of lens materials as linearly elastic.

    • Main Results:

    • The 45-year-old lens model demonstrated significantly reduced accommodative effectiveness compared to the 29-year-old model.
    • The finite element model successfully simulated age-related changes in lens accommodation, indicative of presbyopia.
    • Anomalous behavior was observed in the 11-year-old lens model, prompting further investigation.

    Conclusions:

    • Finite element modeling provides a viable approach to simulating age-related changes in human lens accommodation.
    • The study's findings support the capability of the model to capture key biomechanical aspects of presbyopia.
    • Further research is needed to fully understand the anomalous behavior in younger lens models.