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Related Experiment Videos

Glycated hemoglobin: a useful post-mortem reference marker in determining diabetes.

Jean-Pierre Goullé1, Christian Lacroix, Daniel Bouige

  • 1Laboratoire de Pharmacocinétique et de Toxicologie Cliniques, Groupe Hospitalier, B.P. 24, 76083 Le Havre, France. jgoulle@ch-havre.fr

Forensic Science International
|September 5, 2002
PubMed
Summary

Glycated hemoglobin (HbA1c) is a reliable marker for long-term diabetes management. This study shows HbA1c is stable for months in stored blood, proving useful in forensic investigations.

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Area of Science:

  • Clinical Chemistry
  • Forensic Science
  • Endocrinology

Background:

  • Glycated hemoglobin (HbA1c) is a key indicator of long-term glucose control in diabetes, reflecting average blood glucose over approximately 60 days.
  • The stability of HbA1c in stored blood samples is crucial for its reliable application, particularly in forensic contexts where immediate testing may not be feasible.

Observation:

  • This study investigated the stability of HbA1c at 4 degrees C over time using various anticoagulants and preservatives.
  • High-performance liquid chromatography (HPLC) was employed for semi-automatic HbA1c analysis in 106 tests, including forensic samples.
  • Blood samples collected with fluoride showed good HbA1c conservation for up to 3 months, while dry or heparinized tubes maintained stability for 6 months.

Findings:

Related Experiment Videos

  • HbA1c levels in forensic samples from non-diabetic individuals matched reference values from living controls (3.5-6.25% of total hemoglobin).
  • The HPLC method successfully differentiated diabetic ketoacidosis from alcoholic or starvation ketoacidosis in post-mortem cases by assessing elevated HbA1c.
  • The method was applied successfully in five forensic cases, confirming its utility in post-mortem diagnosis.

    • Implications:

    • HbA1c analysis is a valuable tool in forensic science for post-mortem diagnosis, especially in differentiating diabetic disorders.
    • The stability of HbA1c in stored samples supports its use as a reliable biomarker in challenging forensic investigations.
    • This research validates HbA1c as a crucial forensic marker for diagnosing diabetic conditions posthumously.