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Related Experiment Videos

Hypertrichosis due to diazoxide.

J L Burton, W H Schutt, I W Caldwell

    The British Journal of Dermatology
    |December 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Diazoxide can cause hypertrichosis, a condition of excessive hair growth. The exact cause is unknown but may involve increased blood flow to the skin or elevated cyclic AMP levels.

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    Area of Science:

    • Dermatology
    • Pharmacology

    Background:

    • Hypertrichosis is a rare condition characterized by excessive hair growth.
    • Diazoxide is a medication with vasodilatory properties.

    Observation:

    • Two cases of hypertrichosis were observed in patients treated with diazoxide.
    • The hypertrichosis developed as an adverse effect of diazoxide therapy.

    Findings:

    • The mechanism underlying diazoxide-induced hypertrichosis remains unclear.
    • Potential mechanisms include increased cutaneous perfusion (blood flow to the skin) or elevated intracellular levels of cyclic adenosine monophosphate (cAMP).

    Implications:

    • Understanding the mechanism can help in managing or preventing this side effect.
    • Further research is warranted to elucidate the precise pathway involved in diazoxide-induced hypertrichosis.