Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Messenger RNA decay during aging and development.

Gary Brewer1

  • 1Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA. brewerga@umdnj.edu

Ageing Research Reviews
|September 5, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SARS-CoV-2 Antivirals Identified from Small Molecule Modulators of Programmed -1 Ribosomal Frameshifting.

ACS infectious diseases·2026
Same author

Enterovirus evolution reveals the mechanism of an RNA-targeted antiviral and determinants of viral replication.

Science advances·2024
Same author

The 5'UTR of HCoV-OC43 adopts a topologically constrained structure to intrinsically repress translation.

The Journal of biological chemistry·2023
Same author

The RNA-binding protein AUF1 facilitates Akt phosphorylation at the membrane.

The Journal of biological chemistry·2022
Same author

Acyl-Coenzyme A Synthetase Long-Chain Family Member 4 Is Involved in Viral Replication Organelle Formation and Facilitates Virus Replication via Ferroptosis.

mBio·2022
Same author

Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures.

Science advances·2021
Same journal

White matter abnormalities in Alzheimer's disease: Implications for pathophysiology, diagnosis, and treatment.

Ageing research reviews·2026
Same journal

Preclinical Evidence for Icariin in Alzheimer's Disease: Methodological Quality, Efficacy, and Mechanisms.

Ageing research reviews·2026
Same journal

The Brain Renin-Angiotensin System in Parkinson's Disease: Friend or Foe? Mechanistic Insights and Therapeutic Implications.

Ageing research reviews·2026
Same journal

Effects of nutritional interventions on biomarkers of cellular senescence in humans: a systematic review.

Ageing research reviews·2026
Same journal

Systemic recalibration and epigenetic resetting as complementary strategies in ageing biology.

Ageing research reviews·2026
Same journal

Macrophage Senescence and Programmed Cell Death in Atherosclerosis: Mechanisms, Cross-Talk, and Emerging Therapeutic Strategies.

Ageing research reviews·2026
See all related articles

mRNA decay, a key gene expression regulator, significantly impacts development and aging. Understanding mRNA decay mechanisms reveals crucial control points in gene regulation.

Area of Science:

  • Molecular Biology
  • Genetics
  • Developmental Biology

Background:

  • Gene expression involves transcription, mRNA processing, translation, and decay.
  • Changes in gene expression programs are critical during development, differentiation, and aging.
  • While transcription and protein turnover are known regulators, mRNA decay is increasingly recognized as a major control point.

Purpose of the Study:

  • To survey mRNA decay processes in eukaryotes.
  • To describe molecular mechanisms that alter mRNA decay rates.
  • To highlight the role of mRNA decay in gene expression changes during development and aging.

Main Methods:

  • Literature review and synthesis of current research on mRNA decay.
  • Identification of protein factors, cofactors, and mRNA instability elements involved in decay.

Related Experiment Videos

  • Analysis of molecular mechanisms regulating mRNA decay rates.

    • Main Results:

    • mRNA decay is an orchestrated process involving numerous protein factors and mRNA elements.
    • Specific molecular mechanisms can alter the decay rates of individual mRNAs.
    • These alterations in decay rates contribute significantly to changes in gene expression during development and aging.

    Conclusions:

    • mRNA decay is a crucial regulatory mechanism in eukaryotes.
    • Understanding mRNA decay provides insights into developmental and aging processes.
    • Further research into mRNA decay factors and mechanisms will enhance our comprehension of gene expression control.