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Related Experiment Videos

Human telomerase and its regulation.

Yu-Sheng Cong1, Woodring E Wright, Jerry W Shay

  • 1Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9039, USA. Yu-Sheng.Cong@UTSouthwestern.edu

Microbiology and Molecular Biology Reviews : MMBR
|September 5, 2002
PubMed
Summary
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Telomeres protect chromosome ends and are maintained by telomerase, an enzyme crucial for cell aging and cancer. Understanding telomerase regulation offers potential anti-aging and anti-cancer therapies.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Telomeres are protective caps on eukaryotic chromosomes, vital for genome stability.
  • Telomere length is linked to cellular aging and various diseases.
  • Telomerase, a reverse transcriptase, synthesizes telomeric DNA.

Purpose of the Study:

  • To review the components of the human telomerase complex.
  • To update knowledge on the molecular mechanisms regulating human telomerase.
  • To highlight the therapeutic potential of modulating telomerase activity.

Main Methods:

  • Literature review of telomerase components.
  • Analysis of molecular mechanisms in telomere maintenance.
  • Discussion of telomerase regulation in aging and cancer.

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Main Results:

  • Detailed description of known telomerase complex constituents.
  • Elucidation of key regulatory pathways influencing telomerase activity.
  • Identification of telomerase's role in cell immortalization and tumor progression.

Conclusions:

  • Telomerase is essential for cellular life and implicated in diseases.
  • Understanding telomerase regulation is key for developing anti-aging and anti-cancer treatments.
  • Targeting telomerase offers promising therapeutic strategies.