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Oxidative stress in allergic respiratory diseases
Russell P Bowler1, James D Crapo
1National Jewish Medical and Research Center, Denver, CO 80236, USA.
The Journal of Allergy and Clinical Immunology
|September 5, 2002
Summary
Oxidative stress contributes to allergic disorders like asthma. Reducing exposure to environmental oxidants or boosting antioxidant defenses may help treat these conditions.
Area of Science:
- Immunology
- Environmental Health
- Biochemistry
Background:
- Allergic disorders, including asthma, rhinitis, and atopic dermatitis, are significantly influenced by oxidative stress.
- Oxidative stress is characterized by an excess of reactive oxygen and nitrogen species, leading to cellular damage.
- Environmental factors like air pollution and cigarette smoke contribute to oxidative stress.
Purpose of the Study:
- To explore the role of oxidative stress in allergic disorders.
- To investigate the potential of antioxidant strategies as therapeutic interventions for allergic respiratory conditions.
Main Methods:
- Review of existing evidence on oxidative stress and allergic diseases.
- Analysis of the localization and function of antioxidant enzymes in the lung.
- Examination of the interaction between nitric oxide and reactive oxygen species.
Main Results:
- Oxidative stress is a key mediator in the pathogenesis of allergic disorders.
- Antioxidant enzymes in the lung may act as cell-signaling regulators.
- Reactive oxygen species contribute to cellular damage in allergic conditions.
Conclusions:
- Therapeutic strategies targeting oxidative stress are promising for allergic respiratory disorders.
- Decreasing environmental reactive oxygen species exposure can be beneficial.
- Augmenting endogenous antioxidant defenses may serve as an adjunctive therapy.
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