Related Experiment Video
Updated: Feb 7, 2026
GPI Anchoring of Proteins in the ER Membrane
Stats: transcriptional control and biological impact
1Department of Pathology, New York University School of Medicine, New York, New York 10016, USA.
Abstract:
Extracellular proteins bound to cell-surface receptors can change nuclear gene expression patterns in minutes, with far-reaching consequences for development, cell growth and homeostasis. The signal transducer and activator of transcription (STAT) proteins are among the most well studied of the latent cytoplasmic signal-dependent transcription-factor pathways. In addition to several roles in normal cell decisions, dysregulation of STAT function contributes to human disease, making the study of these proteins an important topic of current research.
Related Concept Videos
GPI Anchoring of Proteins in the ER Membrane
GPI-anchor structure
A sequence of 11 enzymatic reactions results in the synthesis of the complete GPI anchor consisting of a hydrophobic and a hydrophilic portion. The hydrophobic portion comprises phosphatidylinositol, while the hydrophilic part comprises polar groups like phosphoethanolamine,...
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
The Anchoring-and-Adjustment Heuristic
Anchoring Junctions
Lipids as Anchors
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains...
Complement System