Related Experiment Videos
Cardiopulmonary bypass in the cat
Jeff D Brourman1, Eric R Schertel, David W Holt
1Ohio State University College of Veterinary Medicine, Columbus, OH, USA.
Veterinary Surgery : VS
|September 5, 2002
Summary
Cardiopulmonary bypass (CPB) was successfully performed in cats weighing less than 6 kg, demonstrating acute survival and physiologic stability. This study validates the use of a pediatric oxygenator system for feline cardiac surgery.
Area of Science:
- Veterinary Medicine
- Cardiovascular Surgery
- Comparative Physiology
Background:
- Cardiopulmonary bypass (CPB) is a critical procedure in cardiac surgery.
- Its application in small feline patients presents unique challenges.
- Evaluating pediatric human systems for veterinary use is essential for advancing surgical options.
Purpose of the Study:
- To assess the physiological response and acute survival of cats undergoing CPB.
- To determine the efficacy of a commercial human pediatric oxygenator system in cats weighing less than 6 kg.
Main Methods:
- Six intact male cats underwent CPB using cannulation of the vena cavae and carotid artery.
- A pediatric CPB circuit was utilized with a balanced crystalloid prime and vacuum-assist.
- Cardiac arrest was induced for 45 minutes, followed by weaning from bypass and decannulation. Physiological parameters were monitored throughout.
Main Results:
- CPB led to significant decreases in hematocrit and total plasma protein.
- Mean arterial pressure decreased post-CPB, and activated clotting time was managed with heparin and protamine.
- Platelet and white blood cell counts significantly decreased, with one instance of reversible ventricular fibrillation upon reperfusion.
Conclusions:
- Successful cardiopulmonary bypass was achieved in all six cats weighing less than 6 kg.
- Acute survival to 90 minutes post-CPB was demonstrated in all subjects.
- This validates the feasibility of CPB in small cats, potentially enabling intracardiac repair.