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Updated: Sep 29, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
Single-nucleotide polymorphism in the E-cadherin gene promoter modifies the risk of prostate cancer
Bas A J Verhage1, Kjeld van Houwelingen, T Emiel G Ruijter
1Department of Urology (252 EPIB), University Medical Centre Nijmegen, NL-6500 HB Nijmegen, The Netherlands.
Abstract:
E-cadherin plays a major role in intercellular adhesion, cell polarity and tissue architecture. We determined the relative risk of PCa associated with a previously reported C/A SNP at -160 bp relative to the transcription-start site of the E-cadherin gene promoter. Eighty-two PCa patients and 188 controls were genotyped. Genotype and allele frequencies differed significantly among cases and controls. A-allele carriers had a higher relative risk of PCa (OR = 3.6, 95% CI 2.0-6.4) compared to C-only carriers. AC and AA genotypes had an increased risk of PCa (OR = 3.8, 95% CI 2.1-6.8 and OR = 1.7, 95% CI 0.4-6.6, respectively) compared to CC genotypes.
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