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Related Experiment Videos

BMP mRNA and protein expression in the developing mouse olfactory system.

Paolo Peretto1, Diana Cummings, Chiara Modena

  • 1Department of Human and Animal Biology, University of Torino, 10123 Torino, Italy.

The Journal of Comparative Neurology
|September 5, 2002
PubMed
Summary

Bone morphogenetic proteins (BMPs) are crucial for central nervous system development and adult neural plasticity. This study reveals differential expression of BMP4, 6, and 7 in the mouse olfactory system, highlighting their roles in development and adult plasticity.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • Bone morphogenetic proteins (BMPs) are vital for central nervous system (CNS) organization.
  • BMPs are present in adult brain regions exhibiting neural plasticity.
  • The olfactory system offers a unique model for studying continuous cell proliferation and neural differentiation.

Purpose of the Study:

  • To investigate the expression patterns of BMP4, BMP6, and BMP7 mRNAs and proteins within the murine olfactory system.
  • To understand the developmental and adult roles of these specific BMPs in the olfactory epithelium (OE) and olfactory bulb (OB).

Main Methods:

  • Quantitative analysis of BMP4, 6, and 7 mRNA and protein expression.
  • Immunohistochemical staining to visualize protein localization in embryonic, postnatal, and adult murine olfactory tissues.

Related Experiment Videos

  • Microscopic examination of expression patterns in the OE, OB, glomerular layer (GL), mitral cell layer (MCL), and subventricular zone (SVZ)/subependymal layer (SEL).

    • Main Results:

    • BMP4 and BMP7 exhibited similar expression patterns from embryonic day 15.5 through adulthood, localized in the OE, OB nerve layer, GL, MCL, and SVZ/SEL.
    • During the first postnatal week, BMP4 and BMP7 immunoreactivity was prominent in the GL, MCL, and SEL.
    • In adults, BMP4 and BMP7 were found in the GL and SEL, associated with astrocytes.
    • BMP6 immunoreactivity was consistently detected in mature olfactory receptor neurons and their axons projecting to the OB.

    Conclusions:

    • BMPs (specifically BMP4, 6, and 7) show differential expression throughout the development and adult life of the murine olfactory system.
    • These findings support the hypothesis that BMPs are involved in the morphogenesis of the olfactory system during development.
    • BMPs likely contribute to the neural plasticity observed in the adult olfactory system.