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Sensory-predominant, painful, idiopathic neuropathy: inflammatory changes in sural nerves
Praful Kelkar1, Wendy R McDermott, Gareth J Parry
1Department of Neurology, 2 RCP, University of Iowa Hospitals, 200 Hawkins Drive, Iowa City, IA 52242, USA. praful-kelkar@uiowa.edu
Muscle & Nerve
|September 5, 2002
Abstract:
Sensory-predominant, painful, idiopathic neuropathies are a common clinical problem. In this retrospective study of 11 patients with such a neuropathy, we found axonal loss in 9, with multifocal axonal loss in 4 patients; there were large perivascular mononuclear inflammatory infiltrates (>50 cells) in 4 and smaller infiltrates (10-20 cells) in 4. These findings suggest that some cases of this neuropathy may be due to autoimmune vasculopathy and therefore may respond to immunotherapy.