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Updated: Sep 29, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
Long-term follow-up of globus pallidus chronic stimulation in advanced Parkinson's disease
Franck Durif1, Jean-Jacques Lemaire, Bérengère Debilly
1Fédération de Neurologie, Hôpital Gabriel Montpied, Clermont Ferrand, France. fdurif@chu-clermontferrand.fr
Abstract:
To assess the long-term follow-up of the globus pallidus internus (GPi) stimulation, six patients were evaluated every year by using the Unified Parkinson's Disease Rating Scale (UPDRS). Three years postoperatively, GPi stimulation led to a significant improvement of dyskinesia severity (50%, P = 0.05) and activities of daily living (subscore of quality of life scale, 9%, P = 0.05). However, the improvement induced by chronic pallidal stimulation on the mean daily duration in the off state was lost at the last assessment.
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