Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Low-magnitude mechanical loading becomes osteogenic when rest is inserted between each load cycle.

Sundar Srinivasan1, David A Weimer, Steven C Agans

  • 1Department of Orthopedics and Sports Medicine, University of Washington, Seattle 98104-2499, USA.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|September 5, 2002
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genomic determinants of biological age estimated by deep learning applied to retinal images.

GeroScience·2025
Same author

Distinct Genetic Risk Profile in Aortic Stenosis Compared With Coronary Artery Disease.

JAMA cardiology·2024
Same author

A microCT-based platform to quantify drug targeting.

European radiology experimental·2023
Same author

A convolutional neural network to characterize mouse hindlimb foot strikes during voluntary wheel running.

Frontiers in bioengineering and biotechnology·2023
Same author

Beta 2 Adrenergic Receptor Selective Antagonist Enhances Mechanically Stimulated Bone Anabolism in Aged Mice.

JBMR plus·2023
Same author

A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction.

Nature communications·2020

Adding short rest periods to low-magnitude bone loading significantly boosts bone formation. This strategy enhances osteogenic potential, offering a promising approach to combat bone loss through exercise interventions.

Area of Science:

  • Biomedical Engineering
  • Orthopedics
  • Cell Biology

Background:

  • Exercise strategies for bone loss have limited success, especially with mild activities like walking.
  • Low-magnitude mechanical loading is a potential therapeutic approach for bone health.

Purpose of the Study:

  • To investigate if incorporating rest intervals into low-magnitude loading enhances bone formation.
  • To determine the optimal loading parameters for stimulating osteogenesis.

Main Methods:

  • Utilized two in vivo models: avian ulna and murine tibia.
  • Applied low-magnitude mechanical loading with and without 10-second rest intervals between cycles.
  • Measured periosteal and endocortical bone formation rates.

Main Results:

Related Experiment Videos

  • In the avian ulna model, rest intervals significantly increased periosteal labeled surface compared to continuous loading.
  • In the murine tibia model, rest intervals dramatically elevated periosteal bone formation rate.
  • Endocortical bone formation remained unaffected by any loading regimen in both models.

Conclusions:

  • A 10-second rest interval between load cycles greatly enhances the osteogenic potential of low-magnitude loading.
  • This modified loading protocol shows promise for stimulating bone formation and potentially counteracting bone loss.