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[Effect of sodium ferulate on proliferation of rabbit aortic smooth muscle cells induced by oxidized LDL]
Objective:
To investigate the effect of sodium ferulate on the proliferation and lipid peroxidation of aortic smooth muscle cells(SMC).
Method:
Using experimental models of proliferation of cultured rabbit aortic SMC induced by oxidized-low density lipoprotein, the level of lipoperoxide(LPO) was determined by thiobarbituric acid reactive substance(TBARS) method and 3H-thymidine(3H-TdR) incorporation was used to observe DNA synthesis.
Results:
SF markedly reduced the increase of medium LPO and inhibited the 3H-TdR incorporation in a dose-dependent manner.
Conclusion:
SF can inhibit the proliferation of SMC. The inhibitory effect may be related to the inhibition of lipid peroxidation.
