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[Clinical significance of calcitonin expression in lung tissue with bronchiectasis]

Y Yang¹, X M Zhang, J M Luo

¹Department of Geriatrics, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.

Hunan Yi Ke Da Xue Xue Bao = Hunan Yike Daxue Xuebao = Bulletin of Hunan Medical University

|September 6, 2002

Abstract

Objective:

To investigate the relation between the pathologic feature of bronchiectasis and the expression of calcitonin(CT) protein within pulmonary neuroendocrine cells(PNEC) in bronchiectasis.

Method:

CT expression of PNEC was detected using immunohistochemistry(SP method) and quantitative analysis was completed by counting CT positive cell number on per 10 cm length of epithelium.

Result:

CT positive PNEC were found both at all levels of airway tree in all 37 cases of bronchiectasis and 10 cases of control, but none were found in alveolar ducts and alveoli. In bronchiectasis, CT positive PNEC was 67.59 +/- 10.57 per 10 cm length of epithelium, and in control group 5.48 +/- 1.06. Statistical analysis revealed a significant difference between bronchiectasis and control(P < 0.001).

Conclusion:

There was a high level CT expression in bronchiectasis. The PNEC hyperplasia may play a role in the chronic inflammation of bronchiectasis.

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