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Related Experiment Videos

Is the black thyroid really an innocuous pathological finding?

M C Nollevaux1, M Burlet, J P Squifflet

  • 1Départements d'Anatomie Pathologique, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Bruxelles, Belgique.

Acta Clinica Belgica
|September 6, 2002
PubMed
Summary
This summary is machine-generated.

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Minocycline, an antibiotic used for acne, can cause black thyroid discoloration and potential antithyroid effects. Long-term users should have their thyroid function monitored.

Area of Science:

  • Endocrinology
  • Pathology
  • Pharmacology

Background:

  • Thyroid nodules require investigation, sometimes leading to surgical intervention.
  • Minocycline is a commonly prescribed antibiotic for acne vulgaris.
  • Long-term antibiotic use can have unforeseen side effects.

Observation:

  • A 24-year-old woman presented with a cold thyroid nodule.
  • Thyroidectomy revealed a diffusely black-colored specimen.
  • Microscopic examination showed brown granules and intralysosomal lipofuscin-like deposits.

Findings:

  • The observed pathological changes are consistent with "black thyroid".
  • These findings are associated with minocycline intake.
  • The patient had a history of three years of minocycline treatment for acne.

Related Experiment Videos

Implications:

  • Minocycline may induce thyroid pigmentation and potentially affect thyroid function.
  • Monitoring thyroid tests in patients on long-term minocycline therapy is recommended.
  • This case highlights a rare but notable side effect of minocycline treatment.