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A computer-assisted cognitive test battery for aged monkeys.

Jerry J Buccafusco1, Alvin V Terry, Paul B Murdoch

  • 1Alzheimer's Research Center, Medical College of Georgia, Augusta 30912, USA. jbuccafu@mail.mcg.edu

Journal of Molecular Neuroscience : MN
|September 6, 2002
PubMed
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A titrating version of the delayed matching-to-sample (DMTS) task effectively assesses memory in aging macaques. This method adjusts delay intervals, showing age-related performance differences and aiding drug studies for aging.

Area of Science:

  • Neuroscience
  • Primate Cognition
  • Pharmacology

Background:

  • The delayed matching-to-sample (DMTS) task is crucial for evaluating memory-enhancing agents in non-human primates.
  • Fixed delay intervals can cause ceiling effects in monkeys with varied performance efficiencies.
  • Age-dependent memory decline is a significant concern in primate models.

Purpose of the Study:

  • To develop and validate a titrating version of the DMTS task to better assess age-related memory deficits in macaques.
  • To investigate the utility of the titrating DMTS task in identifying age-dependent performance decrements.
  • To establish a sensitive tool for comparing mnemonic drugs in aging animal models.

Main Methods:

  • A computer-assisted, titrating delayed matching-to-sample (DMTS) task was developed.

Related Experiment Videos

  • Delay intervals were adjusted dynamically: incremented after correct responses and decremented after errors.
  • Rhesus and pigtail macaques (5-27 years) performed the task over multiple sessions.

    • Main Results:

    • Maximum delay intervals attained showed a significant positive correlation with age (p < 0.02).
    • Task accuracy and trials completed per session exhibited a trend towards age-related decrements (p < 0.08).
    • Aged macaques were more sensitive to scopolamine and distractors compared to younger animals.

    Conclusions:

    • The titrating DMTS task effectively captures age-related memory performance differences in macaques.
    • This modified task may overcome limitations of fixed-interval DMTS, particularly in aged subjects.
    • The titrating DMTS shows promise as a sensitive tool for evaluating drugs targeting memory in aging populations.