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Related Experiment Videos

Paying hypertension research subjects.

David Casarett1, Jason Karlawish, David A Asch

  • 1Center for Health Equity Research and Promotion at the Philadelphia Veterans Affairs Medical Center, Philadelphia, Pa, USA. Casarett@mail.med.upenn.edu

Journal of General Internal Medicine
|September 6, 2002
PubMed
Summary

Most people believe research payments could unduly influence others, especially those with lower incomes. However, they feel such payments would not affect their own judgment when considering clinical trial participation.

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Area of Science:

  • Bioethics
  • Clinical Research Ethics
  • Informed Consent

Background:

  • Cash payments are common compensation for research participants.
  • Ethical concerns exist that these payments may constitute an undue inducement, potentially compromising informed consent.
  • The theoretical argument of undue inducement requires empirical investigation.

Purpose of the Study:

  • To assess public agreement with the ethical argument that research payments can be an undue inducement.
  • To explore whether potential research participants perceive payments as impairing careful consideration of risks and benefits.

Main Methods:

  • A survey was conducted with 350 prospective jurors.
  • Participants were asked about their beliefs regarding a $500 payment for research participation.
Keywords:
Biomedical and Behavioral ResearchEmpirical Approach

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  • Key outcome measures included beliefs about payment influencing judgment and self-perception of influence.

    • Main Results:

    • A significant majority of jurors (74.6%) believed a $500 payment would impair subjects' ability to weigh research risks and benefits.
    • This concern was particularly pronounced for participants with lower incomes.
    • Conversely, only 19.7% of jurors believed the payment would influence their own decision-making, with lower income and education correlating with higher perceived influence.

    Conclusions:

    • The general public shares ethical concerns regarding the influence of research payments.
    • Individuals tend to believe these concerns are more applicable to others than to themselves.
    • Findings highlight a potential disconnect between perceived ethical risks and personal vulnerability to financial incentives in research.