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Age-related changes in plasma orexin-A concentrations.
Takeshi Matsumura1, Mika Nakayama, Akihiro Nomura
1Department of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennoudai Tsukuba, Ibaraki 305-8575, Japan.
Experimental Gerontology
|September 6, 2002
Summary
Plasma orexin-A levels increase with age in healthy adults. Concentrations were significantly higher in individuals over 60 compared to those under 39, suggesting orexin-A
Area of Science:
- Neuroscience
- Endocrinology
- Gerontology
Background:
- Orexin-A is a neuropeptide involved in regulating sleep-wake cycles and appetite.
- The role of orexin-A in the aging process is not well understood.
Purpose of the Study:
- To investigate the relationship between aging and plasma orexin-A concentrations in healthy individuals.
Main Methods:
- Plasma orexin-A levels were measured in 82 healthy volunteers (23-79 years old).
- Correlation analyses were performed to assess the association between age and orexin-A levels.
- Participants were divided into three age groups for comparison.
Main Results:
- Plasma orexin-A concentrations showed a significant positive correlation with age (r = 0.50, P < 0.01).
- Individuals over 60 years old had significantly higher orexin-A levels than those under 39 years old (P < 0.05).
Conclusions:
- Orexin-A levels increase with age in a healthy population.
- These findings suggest a potential involvement of orexin-A in the aging process.