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Wegener's granulomatosis presenting as necrosis of the left mainstem bronchus
Paul Schneider1, Jörn Gröne, Jürgen Braun
1Department of General, Vascular and Thoracic Surgery, Benjamin Franklin Medical Center Freie Universität Berlin, Berlin, Germany. p.schneider@ukbf.fu-berlin.de
Abstract:
A patient with pansinusitis, nasal septum necrosis, and saddle nose deformity showed necrosis of the left mainstem, upper, and lower bronchi, with complete loss of left lung perfusion and ventilation. Pneumonectomy was performed. Histological findings showed extensive necrotizing and granulomatous bronchial inflammation with vasculitis of the bronchial arteries and the pulmonary vein. Wegener's granulomatosis was diagnosed, despite a negative cytoplasmic pattern of antineutrophil cytoplasmic antibodies and the lack of renal involvement.
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