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Related Experiment Videos

Vaginal Escherichia coli share common virulence factor profiles, serotypes and phylogeny with other extraintestinal

Mana Obata-Yasuoka1,2, William Ba-Thein1, Teizo Tsukamoto1

  • 1Osaka Prefectural Institute of Public Health, OSaka, 537-0025, Japan2.

Microbiology (Reading, England)
|September 6, 2002
PubMed
Summary

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Vaginal Escherichia coli (VEC) strains share virulence factors and genetic traits with those causing urinary tract and neonatal infections. These VEC may act as a reservoir for extraintestinal E. coli infections.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Genetics

Background:

  • The role of vaginal Escherichia coli (VEC) in extraintestinal infections remains poorly understood.
  • Investigating VEC characteristics is crucial for understanding transmission routes of E. coli infections.

Purpose of the Study:

  • To characterize VEC isolates from Japanese women.
  • To determine the prevalence of virulence factors and serotypes in VEC.
  • To compare VEC with other pathogenic E. coli strains.

Main Methods:

  • Characterization of 88 VEC isolates using virulence factor profiling, O:H serotyping, and phylogenetic analysis.
  • Comparative analysis with stool isolates and previous study data.

Main Results:

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  • High prevalence of virulence factors like PAI (78%) and papC (45%) in VEC.
  • Phylogenetic groups B2 (76%) and D (16%) were dominant in VEC strains.
  • VEC strains shared common virulence profiles, serotypes, and phylogeny with uropathogenic and neonatal pathogenic E. coli.

Conclusions:

  • Vaginal E. coli possess virulence factors and genetic characteristics similar to pathogenic strains.
  • VEC may serve as a reservoir for extraintestinal E. coli infections, highlighting a 'faecal-vaginal-urinary/neonatal' transmission pathway.