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Ku affects the ATM-dependent S phase checkpoint following ionizing radiation

Xiang-Yang Zhou1, Xiang Wang, Hongyan Wang

  • 1Department of Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, PA 19107, USA.

Oncogene
|September 6, 2002
PubMed
Summary

Genotoxic stress triggers cell cycle arrest for DNA repair. Ku80-deficient cells show a stronger S phase checkpoint response due to increased ATM kinase activity following irradiation.

Keywords:
Non-programmatic

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