Pharmacokinetics of practolol in the rabbit with experimental glomerulonephritis

The pharmacokinetics of practolol were studied after intravenous injection (5 mg/kg) in conscious normal rabbits and rabbits with experimental glomerulonephritis induced by daily intravenous injection of bovine gamma-globulin. The results obtained demonstrated that the practolol elimination was impaired in animals with experimental glomerulonephritis: significant lengthening of the half-life of the beta-phase, with marked decrease of the body clearance and diminution of the drug concentration decrease in plasma. Neither conjugates nor deacetylpractolol could be detected in the urine of the controls or immunized rabbits.