Effect of crystal form on in vivo topical anti-inflammatory activity of corticosteroids
Young-Taek Sohn1, Sun-Young Kim
1College of Pharmacy, Duksung Womenis University, Tobong-Gu, Seoul, Korea. ytsohn@center.duksung.ac.kr
Abstract:
The aim of this study was to gain information on the effects of the crystal form of corticosteroids on the topical anti-inflammatory activity. Two different crystal forms, Form A and Form B, of the drugs of prednicarbate, hydrocortisone, betamethasone 17-valerate, prednisolone, and methyl prednisolone were prepared and their topical anti-inflammatory activities were measured using arachidonic acid induced ear edema assay in mice. Two crystal forms of the drugs showed differences in anti-inflammatory activity. Among the drugs examined, Form B of prednicarbate and betamethasone 17-valerate showed significantly more potent anti-inflammatory activities as compared to their Form A.
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