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Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats
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Sibling resemblance for left ventricular structure, contractility, and diastolic filling.

Weihong Tang1, Donna K Arnett, Richard B Devereux

  • 1Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, USA.

Hypertension (Dallas, Tex. : 1979)
|September 7, 2002
PubMed
Summary
This summary is machine-generated.

Familial factors significantly influence left ventricular (LV) diastolic filling and structure in hypertension. Shared genetic or environmental factors link early and late filling parameters, and relaxation time with wall thickness.

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Area of Science:

  • Cardiology
  • Genetics
  • Hypertension Research

Background:

  • Left ventricular (LV) function is known to be genetically influenced.
  • The specific contribution of familial factors to LV diastolic filling, contractility, and structure variations remains unclear.

Purpose of the Study:

  • To investigate the role of familial factors in the variation and covariation of LV diastolic filling, contractility, and structure.
  • To estimate single- and cross-trait sibling correlations for key LV parameters in hypertensive sibships.

Main Methods:

  • Bivariate familial correlation models were applied to hypertensive sibling pairs (200 white, 374 black).
  • Measured parameters included LV transmitral peak filling velocities, isovolumic relaxation time, atrial filling fraction, stress-corrected midwall shortening, and LV mass/structure.
  • Analyses were adjusted for covariates in race-specific linear regression models.

Main Results:

  • Single-trait sibling correlation was highest for early peak filling velocity.
  • Significant cross-trait correlations were found between early and late peak filling velocities.
  • In white participants, correlations were also observed between early peak filling velocity and atrial filling fraction, and between isovolumic relaxation time and end-diastolic posterior wall thickness.

Conclusions:

  • Significant cross-trait sibling resemblance suggests pleiotropy or shared environmental influences on LV diastolic parameters and structure.
  • These findings are crucial for understanding the heritability of left ventricular diastolic function in hypertensive individuals.