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Related Experiment Videos

Normocalcemic primary hyperparathyroidism with fractures.

Po-Hui Wu1, Ching-Jen Wang

  • 1Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Kaohsiung, Taiwan. w62102@ms8.hinet.net

The Journal of Arthroplasty
|September 7, 2002
PubMed
Summary
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This study reports the first case of normocalcemic primary hyperparathyroidism presenting as bilateral femoral neck fractures. Surgical treatment and parathyroidectomy led to a successful clinical outcome.

Area of Science:

  • Endocrinology
  • Orthopedic Surgery
  • Nephrology

Background:

  • Normocalcemic primary hyperparathyroidism is a rare endocrine disorder.
  • It is typically associated with urinary stones, not skeletal fractures.
  • This presentation highlights an unusual manifestation of the condition.

Observation:

  • A 45-year-old man presented with hip pain and limping.
  • Radiographs revealed vertical fractures of bilateral femoral necks.
  • Laboratory tests showed normal total calcium but elevated ionized calcium, parathyroid hormone, and alkaline phosphatase.

Findings:

  • The patient was diagnosed with normocalcemic primary hyperparathyroidism.
  • Surgical intervention included subtrochanteric valgus osteotomy with dynamic hip screw fixation and total parathyroidectomy.

Related Experiment Videos

  • Histopathology confirmed parathyroid gland hyperplasia.

    • Implications:

    • This case expands the known clinical spectrum of normocalcemic primary hyperparathyroidism.
    • It underscores the importance of considering hyperparathyroidism in patients with unexplained fractures, even with normal serum calcium.
    • Early diagnosis and surgical management can lead to favorable patient outcomes.