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Acute propylene glycol ingestion.

Daniel E Brooks1, Kevin L Wallace

  • 1Department of Medical Toxicology, Good Samaritan Regional Medical Center, Phoenix, Arizona 85006, USA. dbmdtox@aol.com

Journal of Toxicology. Clinical Toxicology
|September 10, 2002
PubMed
Summary

This case study shows that ethanol may inhibit propylene glycol metabolism, leading to a slower elimination. Further research is needed to understand ethanol's effect on propylene glycol intoxication outcomes.

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Area of Science:

  • Toxicology
  • Pharmacokinetics

Background:

  • Acute propylene glycol toxicity can occur following ingestion of antifreeze.
  • Co-ingestion of ethanol may influence propylene glycol metabolism and elimination.

Observation:

  • A 61-year-old male presented with acute ingestion of antifreeze containing ethanol and propylene glycol.
  • Serial measurements revealed a maximum serum propylene glycol concentration of 470 mg/dL, with a nonlinear decline over 57 hours.
  • The patient experienced mild lactate elevation and normal CO2 levels, with unremarkable clinical presentation.

Findings:

  • Propylene glycol elimination followed a nonlinear pattern, consistent with ethanol-induced metabolic inhibition.
  • Absence of significant acid-base disturbance and minimal lactate elevation suggest a protective effect of ethanol.

Implications:

  • Ethanol may alter the toxicokinetics of propylene glycol, potentially influencing clinical outcomes.
  • Understanding ethanol-propylene glycol interactions is crucial for managing antifreeze poisoning cases.

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