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Updated: Aug 19, 2026
Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts
Published on: February 24, 2015
Solid-phase synthesis of alkyl aryl ethers via the Ullmann condensation
Xiao-Yi Xiao1, Rongshi Li, David Hurst
1Bristol-Myers Squibb Company, Experimental Station, E500-4206, Route 141 & Henry Clay Road, Wilmington, DE 19880-0500, USA. xiao-yi.xiao@syrrx.com
Abstract:
Alkyl aryl ether formation is a frequently employed reaction in organic synthesis. Ullmann condensation is an alternative method to the widely used Mitsunobu reaction and is very useful in situations where application of the Mitsunobu reaction is limited. By application of this reaction to solid-phase synthesis of a series of alkyl aryl ethers, reaction conditions (catalyst, solvent, temperature, time, etc.) for a sterically hindered class of alcohols were investigated and optimized. A range of aryl halides was used to explore the scope of the reaction in solid phase.
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