Related Experiment Videos
[Serotonergic activity and harm avoidance in abstinent drug addicts]
C Gómez-Perretta De Mateo1, M Portolés Sanz, M I Pérez Díaz
1Centro de Investigación, Hospital Universitario La Fe, Valencia, Spain. gomez_cla@gva.es
Introduction:
The present study was to assess the relationship between the Tridimensional Personality Questionnaire scores and the 5-HT activity in abstinent drug addicts.
Methodology:
16 men who satisfied the DSM-III-R/DSM-IV criteria for substance abuse disorder accomplished the Cloninger's Tridimensional Personality Questionnaire; their serotonergic activity was measured using the Fenfluramine Challenge Test.
Results:
The Novelty Seeking is the only dimension showing a statistical difference versus a standard healthy sample, while harm avoidance and not the other dimensions was significantly correlated with the prolactin post-fenfluramine peak (r= 0.80, p<0.001).
Conclusion:
This work confirm that drug addicts are high Novelty Seekers and support the hypothesis that Harm Avoidance dimension correlate with serotonergic activity.