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Efficient liquid-phase synthesis of 2'-hydroxychalcones
Edmont V Stoyanov1, Yves Champavier, Alain Simon
1Department of Industrial Pharmacy, Faculty of Pharmacy, Sofia, Bulgaria. estoyanov@yahoo.com
Bioorganic & Medicinal Chemistry Letters
|September 10, 2002
Abstract:
The condensation of 2'-hydroxyacetophenone (1) with aromatic aldehydes (2) in a well closed vessel using microwave irradiation or classical heating at 132 degrees C, provides a fast and simple method for the liquid-phase synthesis of 2'-hydroxychalcones without formation of by-products. Antiproliferative activity of these compounds were evaluated using MCF-7 cells.