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Updated: Sep 29, 2026

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
Synthesis and antiviral/antiproliferative activity of some N-sulphonylbenzimidazoles
Laura Garuti1, Marinella Roberti, Erik De Clercq
1Department of Pharmaceutical Science, University of Bologna, via Belmeloro 6, I-40126 Bologna, Italy. lauga@alma.unibo.it
Abstract:
Some benzimidazolyl sulphones were synthesized and evaluated for their antiviral and antiproliferative properties. Compound 10 displayed significant and selective activity against human cytomegalovirus (CMV), compound 14 showed activity against varicella zoster virus (VZV). The compounds were further evaluated for inhibitory effect on the proliferation of murine leukemia cells and human T-lymphocyte cells. Marked cytotoxicity was noted with different derivatives. Some structure-activity relationships are discussed.
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