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Synthesis and anticancer evaluation of vitamin K(3) analogues
Chinpiao Chen1, Yi-Zhong Liu, Kak-Shan Shia
1Department of Chemistry, National Dong Hwa University, Shoufeng, Hualien, Taiwan, ROC. chinpiao@mail.ndhu.edu.tw
Bioorganic & Medicinal Chemistry Letters
|September 10, 2002
Abstract:
Novel vitamin K(3) analogues were synthesized and evaluated for their anticancer activity. Compound 6, 9, 10, 11, 14, and (+/-)15 demonstrated a strong inhibitory activity against the tumor cells of A-549, Hep G2, MCF7, MES-SA, MES-SA/Dx5, MKN45, SW-480, and TW-039. Compound (+/-)15 displayed potent tumor cell cytotoxicity, and compound 14 selectively affected MCF7, even though it did not influence normal cells Detroit551 and WI-38. Compound (+/-)15 inhibited MES-SA and MES-SA/Dx5, and this specific result shows that compound (+/-)15 may become a good anticancer drug candidate.