Related Experiment Videos
Quantitative aspects of signal transduction by the receptor with high affinity for IgE
Henry Metzger1, Santa Eglite, Hana Haleem-Smith
1Section on Chemical Immunology, Arthritis and Rheumatism Branch, Rm. 9N-228, 10 Center Drive, MSC 1820, NIAMS, NIH, Bethesda, MD 20892-1820, USA. metzgerh@exchange.nih.gov
Molecular Immunology
|September 10, 2002
Abstract:
Identification of the major components, how these interact with each other, and the modifications that follow in the sequence of events triggered by the receptor with high affinity for IgE, is progressing rapidly. A new challenge is to understand these interactions quantitatively. We present the fundamentals of the mechanistic model we are testing through mathematical modeling. The object is to see if the predictions of the model fit with the experimental results.