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Updated: Aug 10, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
Published on: May 27, 2015
Immunoregulatory properties of mast cell-derived exosomes
Dimitris Skokos1, Hany Goubran-Botros, Michèle Roa
1Unité d'Immuno-allergie, Institut Pasteur, 25 rue Dr Roux, 75724 Cedex 15, Paris, France.
Abstract:
Transmission of information from mast cells to neighboring or distant cells must be established continuously in order to ensure homeostasis or to initiate immune and inflammatory responses. Owing to their strategic location in peripheral tissues and their prompt response to various stimuli, mast cells can be considered as the cell prototype to fulfill such a sentinel function. There are several ways for mast cells to communicate with other cells including cell-cell interactions via membrane-associated receptors, cytokines and other soluble mediators, and a newly described messenger which consists of membrane vesicles called exosomes carrying a number of immunoregulatory molecules.
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