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Aggressive intracranial fibromatosis: case report
B Jenny1, A H Kaye, M F Gonzales
1Department of Neurosurgery, The Royal Melbourne Hospital, University of Melbourne, Australia.
Summary
Aggressive fibromatosis in the skull base is rare, often affecting younger patients. This case highlights a rare adult presentation requiring aggressive multimodal treatment for local control.
Area of Science:
- Neuro-oncology
- Surgical Pathology
Background:
- Fibromatosis is a locally aggressive fibroblastic tumor.
- Intracranial fibromatosis is exceptionally rare, typically seen in pediatric patients.
Observation:
- A 48-year-old woman presented with aggressive skull base fibromatosis.
- The tumor infiltrated the sphenoid sinus, pterygoid recesses, cavernous sinus, sella, clivus, petrous bone, and mastoid.
Findings:
- The patient underwent partial resection via an extended trans-sphenoidal approach.
- Postoperative imaging revealed residual tumor, indicating the infiltrative nature of the lesion.
Implications:
- Complete resection of intracranial fibromatosis is challenging due to its infiltrative growth.
- Multimodal therapy including radiotherapy and chemotherapy is often necessary for effective local control.