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Adiponectin is not altered with exercise training despite enhanced insulin action
Matthew W Hulver1, Donghai Zheng, Charles J Tanner
1Department of Physiology, East Carolina University, Greenville North Carolina 27858, USA. hulverm@mail.ecu.edu
American Journal of Physiology. Endocrinology and Metabolism
|September 10, 2002
Summary
Exercise training improves insulin sensitivity but does not alter plasma adiponectin levels. Weight loss, however, significantly increases adiponectin and enhances insulin action, suggesting adiponectin is not linked to exercise-induced insulin sensitivity improvements.
Area of Science:
- Endocrinology
- Metabolic Health
- Exercise Physiology
Background:
- Adiponectin, an adipocytokine, is implicated in regulating insulin action.
- Understanding adiponectin's role in exercise-induced metabolic improvements is crucial.
Purpose of the Study:
- To investigate the relationship between plasma adiponectin levels and enhanced insulin action following exercise training.
- To compare the effects of exercise training versus weight loss on adiponectin and insulin sensitivity.
Main Methods:
- Assessed insulin sensitivity index (S(I)), glucose, insulin, and adiponectin before and after 6 months of consistent exercise training.
- Maintained body mass and fat mass throughout the exercise intervention.
- Examined adiponectin and insulin sensitivity changes in a separate cohort undergoing weight loss.
Main Results:
- Exercise training significantly improved insulin action (S(I) +98%, P < 0.05) without altering plasma adiponectin concentrations.
- Weight loss led to a substantial increase in adiponectin (+281%) accompanied by enhanced insulin action (S(I) +432%).
Conclusions:
- Plasma adiponectin levels do not appear to be a contributing factor to the improvements in insulin sensitivity observed after exercise training.
- Adiponectin levels are significantly elevated with weight loss, correlating with improved insulin action.