Related Experiment Videos
Sclerosing encapsulating peritonitis: regional changes of peritoneum
Kazuyoshi Okada1, Yoshihiko Onishi, Toshinori Oinuma
1Second Department of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo 173-8610, Japan. kokada@med.nihon-u.ac.jp
Nephron
|September 10, 2002
Summary
Sclerosing encapsulating peritonitis (SEP) involves peritoneal membrane thickening. Mechanical stress from shortened mesentery may contribute to SEP development and associated ileus.
Area of Science:
- Nephrology
- Gastroenterology
- Pathology
Background:
- Sclerosing encapsulating peritonitis (SEP) is a severe condition characterized by peritoneal membrane thickening.
- This case report details a patient with end-stage renal failure undergoing dialysis, who developed SEP.
- The patient presented with ileus and was diagnosed with SEP post-mortem.
Observation:
- The patient exhibited regional peritoneal changes, particularly in areas with free mesenteric margins.
- Autopsy revealed a retracted and shortened mesentery root.
- Calcification and ossification were observed in the free margin of the small bowel mesentery.
Findings:
- Mechanical stress, particularly from the retracted mesentery, appears to contribute to SEP.
- Fibrosis extending into the bowel's muscle layer likely caused dysfunction and obstruction, leading to ileus.
- A relationship between calcification, ossification, and SEP in the mesentery is suggested.
Implications:
- Understanding the role of mechanical stress in SEP pathogenesis is crucial for patient management.
- Further research into the link between mesenteric changes, calcification, and SEP is warranted.
- This case highlights the complex interplay of factors contributing to SEP in dialysis patients.